In arterial hypertension, endothelial dysfunction and vascular remodeling may be associated with alteration of platelet function.
Purpose: Study of platelet aggregation parameters in hypertensive elderly patients under treatment.
Material and Method: Platelet aggregation (PA) in relation to blood pressure (BP), treatment, and echocardio-graphic parameteres were evaluated in elderly hypertensive patients. Parameters of PA measured by spectro-photometry at 5, 10 and 15 min after adenosine diphosphate addition were: aggregation at baseline (BAgg), maximum platelet deformation (MPD), maximal aggregation (MaxAgg), time until MaxAgg (TMaxAgg), total aggregation (TA) and disaggregation up to 15 min.
Results: 32 hypertensive patients (study group), 14 males (43.7%), mean age 73.4 ± 9.3 years, were compared to 11 healthy volunteers (control group). The PA parameters were not significantly different between groups, although BAgg and MPD were higher in hypertensive patients. Older age correlated with MPD (r = 0.35, p = 0.04) and aggregation at 5 min (r =0.3, p =0.04). BP values correlated positively with TMaxAgg (r = 0.42, p = 0.01) and negative with disaggregation (r =-0.36, p=0.04). Left ventricle EF was positively associated with MaxAgg (r =0.45, p=0.009) and MM correlated negatively with TMaxAgg (r =-0.4, p=0.01).
Conclusions: In elderly patients with high blood pressure there is an increased risk of thrombogenesis due to an early increase in platelet aggregation and by a delayed disaggregation process of circulating platelets. Further studies are necessary to see if these patients would benefit from early antiplatelet therapy, in preventing thromboembolic events.
Platelets, thrombogenesis, aggregability, maximal deformation, adenosine diphosphate, disaggrega-tion, high blood pressure, endothelial dysfunction
Article in "Journal of HYPERTENSION RESEARCH - www.hypertens.org/jhr" - Accepted: December 13, 2018
Authors: Andreea Stela Liteanu (Serban), Andreea Simona Hodorogea, Paul Gabriel Ruzsa, Cristina
Petrovschi, Camelia Nicolae, Irina Parvu, Adriana Mihaela Iliesiu, Ioan Tiberiu Nanea
Cardiology Department, “Prof. Th. Burghele” Hospital, Bucharest, Romania
